It has long been known that the drug Remdesivir works against the coronavirus. However, in earlier research only a limited spectrum of its mode of action was determined, which only had limited possibilities in the fight against SARS-CoV-2. However, researchers have now discovered a new, significant efficacy that gives science hope in the course of drug development against the pandemic.
The drug with the most powerful effects
Remdevisir has long been considered the drug with the greatest potential for combating SARS-CoV-2 – but so far this unique selling point has not been sufficient for the introduction of an effective drug. A team of scientists from the Goethe University in Frankfurt and the Swiss Paul Scherrer Institute have now been able to draw the following findings from their current study: The drug Remdevisir is able to fight off the proteins of the virus, which the Covid-19 pathogen is used to deceive ours Immune system releases.
Medicines block the pathogen from multiplying
When SARS-CoV-2 attacks our body’s own cells, they not only serve as a host for its own reproduction. The virus is also able to stop the mechanisms that our cells release to defend themselves. This in turn prevents other cells from “rushing to help” the host in order to fend off the attack by the virus. SARS-CoV-2 makes our cells powerless and mute so that nothing stands in the way of its reproduction. In this regard, the drug Remdevisir is interesting: This can namely curb the virus growth of RNA viruses – to which SARS-CoV-2 belongs. The drug interferes with the protein, RNA polymerase, which is necessary for the replication of the virus genome.
Another ability: Remdevisir prevents muting
In detail, this works because when Remdevisir enters the cell, it goes through a stage of development in which it also has virostatic properties. The drug also has the ability to block the virus protein of the attacker SARS-CoV-2 – which prevents the host cell from taking any defensive measures. This drug is thus able to curb the replication of the virus as well as the “muting” of the host cell. Remdevisir therefore has very important properties in the fight against the coronavirus.
Also helpful in the fight against other viruses
In the course of the study, the researchers were able to analyze these processes in detail and thus laid a good basis for creating a drug against SARS-CoV-2. But not only that: The findings from this research can also be of great relevance for the introduction of further drugs against other (even more potent) viruses. This is because the structure of various coronaviruses such as the MERS-CoV or SARS-CoV, but also of some alphaviruses, does not differ significantly. According to the experts, this knowledge could also be very helpful in preparing for the potential following pandemics.
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Forum›Health›Remdesivir: can this drug outsmart SARS-CoV-2?